Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | CA12 | O43570 | 1/20 | 0.64 |
| ▸ | CA1 | P00915 | 1/20 | 0.64 |
| ▸ | CA2 | P00918 | 1/20 | 0.64 |
| ▸ | CA9 | Q16790 | 1/20 | 0.64 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.47 |
| ▸ | STK17B | O94768 | 1/20 | 0.47 |
| ▸ | TXN | P10599 | 1/20 | 0.46 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.46 |
| ▸ | TDO2 | P48775 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | POLA1 | P09884 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1392126 | 0.89 | APP (0.77) | APPMAPK1CA12CA1CA2 | |
| SCHEMBL17220462 | 0.82 | MAPK1 (0.60) | APPMAPK1CA12CA1CA2 | |
| SCHEMBL10016362 | 0.81 | MAPK1 (1.00) | APPMAPK1CA12CA1CA2 | |
| SCHEMBL17220026 | 0.80 | MAPK1 (0.57) | APPMAPK1CA12CA1CA2 | |
| SCHEMBL17220029 | 0.80 | MAPK1 (0.57) | APPMAPK1CA12CA1CA2 | |
| SCHEMBL17220028 | 0.80 | MAPK1 (0.57) | APPMAPK1CA12CA1CA2 | |
| SCHEMBL8525007 | 0.79 | MEN1 (0.53) | APPMAPK1BRAFTXN | |
| SCHEMBL8524506 | 0.78 | MAPT (0.57) | MAPK1BRAFEGFR | |
| SCHEMBL8524268 | 0.77 | MAPT (0.51) | APPMAPK1CA12CA1CA2 | |
| SCHEMBL14869790 | 0.77 | POLA1 (0.63) | MAPK1CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616465-B1 | TRIAZINE-OXADIAZOLES | NOVARTIS AG (CH) | 2015-11-04 | — | — | EP | disclosed |