Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.56 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 6/20 | 0.49 |
| ▸ | JAK1 | P23458 | 5/20 | 0.49 |
| ▸ | JAK3 | P52333 | 3/20 | 0.49 |
| ▸ | IKBKB | O14920 | 7/20 | 0.47 |
| ▸ | CHUK | O15111 | 6/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | NEK1 | Q96PY6 | 5/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20879725 | 0.79 | AURKB (0.70) | AURKAAURKBINCENPTPX2JAK2 | |
| SCHEMBL16673732 | 0.78 | GRM4 (0.60) | AURKAAURKBINCENPTPX2JAK2 | |
| SCHEMBL4792437 | 0.78 | IKBKB (0.74) | AURKBJAK2JAK3IKBKBCHUK | |
| SCHEMBL23543160 | 0.77 | AURKB (0.66) | AURKAAURKBINCENPTPX2JAK2 | |
| SCHEMBL100470 | 0.77 | AURKA (0.54) | AURKAAURKBINCENPTPX2JAK2 | |
| SCHEMBL29540505 | 0.77 | AURKA (0.54) | AURKAAURKBINCENPTPX2JAK2 | |
| SCHEMBL14052556 | 0.76 | AURKB (0.65) | AURKAAURKBINCENPTPX2JAK2 | |
| SCHEMBL100071 | 0.75 | AURKB (0.63) | AURKAAURKBINCENPTPX2JAK2 | |
| SCHEMBL98999 | 0.75 | AURKB (0.62) | AURKAAURKBINCENPTPX2JAK2 | |
| SCHEMBL29540838 | 0.75 | AURKB (0.62) | AURKAAURKBINCENPTPX2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2455382-B1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2016-10-26 | — | — | EP | disclosed |
| EP-2343299-B1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE CORP (US) | 2015-11-04 | — | — | EP | disclosed |