Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.76 |
| ▸ | OGA | O60502 | 15/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL460094 | 0.91 | SMN1; SMN2 (0.62) | SMN1; SMN2OGAHTTMAPK1 | |
| SCHEMBL16113454 | 0.86 | SMN1; SMN2 (1.00) | SMN1; SMN2OGAHTTMAPK1 | |
| SCHEMBL3761918 | 0.83 | SMN1; SMN2 (0.81) | SMN1; SMN2OGAHTT | |
| SCHEMBL13128868 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2OGAHTT | |
| SCHEMBL20281964 | 0.82 | SMN1; SMN2 (0.74) | SMN1; SMN2OGA | |
| SCHEMBL16113448 | 0.81 | SMN1; SMN2 (0.76) | SMN1; SMN2OGA | |
| SCHEMBL8834765 | 0.80 | CCNE1 (0.52) | SMN1; SMN2OGAMAPK1 | |
| SCHEMBL1031633 | 0.80 | SMN1; SMN2 (0.47) | SMN1; SMN2OGAHTTMAPK1 | |
| SCHEMBL28166585 | 0.80 | SMN1; SMN2 (0.53) | SMN1; SMN2OGAHTTMAPK1 | |
| SCHEMBL22004720 | 0.79 | OGA (0.65) | SMN1; SMN2OGA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403833-A1 | 8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101949-A1 | 8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010101949-A1 | 8-SUBSTITUTED QUINOLINES AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2010-09-10 | — | — | WO | disclosed |