Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 3/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
| ▸ | ALPG | P10696 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL122179 | 0.89 | PDE10A (0.43) | CNR1CNR2SMODRD2DRD4 | |
| Hydrochloric Acid SCHEMBL125616 | 0.88 | PDE10A (0.43) | CNR1CNR2SMODRD2DRD4 | |
| SCHEMBL172372 | 0.87 | CNR1 (0.42) | CNR1CNR2SMODRD2DRD4 | |
| SCHEMBL170286 | 0.87 | CNR1 (0.42) | CNR1CNR2SMODRD2DRD4 | |
| SCHEMBL170321 | 0.87 | CNR1 (0.40) | CNR1CNR2SMODRD2DRD4 | |
| SCHEMBL12742533 | 0.87 | CNR1 (0.40) | CNR1CNR2SMODRD2DRD4 | |
| Hydrochloric Acid SCHEMBL123007 | 0.86 | CNR1 (0.42) | CNR1CNR2SMODRD2DRD4 | |
| SCHEMBL172325 | 0.86 | CNR1 (0.42) | CNR1CNR2SMODRD2DRD4 | |
| Hydrochloric Acid SCHEMBL124394 | 0.86 | CNR1 (0.42) | CNR1CNR2SMODRD2DRD4 | |
| Hydrochloric Acid SCHEMBL123983 | 0.86 | CNR1 (0.39) | CNR1CNR2SMODRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2201002-B1 | 5-HT7 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2009048765-A1 | 5-HT7 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2009-04-16 | — | — | WO | disclosed |