SCHEMBL17225997

SCHEMBL17225997

Cc1cc2c3c(cc(C)c4c5ccc6c7c(ccc(c1c34)c75)C(=O)NC6=O)C(=O)NC2=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 4/20 0.40
MEN1 O00255 4/20 0.39
KMT2A Q03164 4/20 0.39
NPSR1 Q6W5P4 2/20 0.39
MAPT P10636 2/20 0.39
CYP3A4 P08684 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
RGS12 O14924 1/20 0.39
USP2 O75604 1/20 0.39
CYP1A2 P05177 1/20 0.39
POLB P06746 1/20 0.39
THRB P10828 1/20 0.39
CYP2C9 P11712 1/20 0.39
APEX1 P27695 1/20 0.39
CASP1 P29466 1/20 0.39
BRCA1 P38398 1/20 0.39
MTOR P42345 1/20 0.39
RECQL P46063 1/20 0.39
BLM P54132 1/20 0.39
CASP7 P55210 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17225996 0.95 PARP1 (0.41) PARP1MEN1KMT2ANPSR1MAPT
SCHEMBL13606621 0.85 PARP1 (0.32) PARP1MEN1KMT2ANPSR1MAPT
SCHEMBL19135937 0.84 CDK4 (0.38) PARP1MEN1KMT2ANPSR1MAPT
SCHEMBL13610173 0.81 PARP1 (0.33) PARP1MEN1KMT2ANPSR1MAPT
SCHEMBL13610506 0.79 PARP1 (0.34) PARP1MEN1KMT2ANPSR1MAPT
SCHEMBL12744308 0.79 NPSR1 (0.44) PARP1MEN1KMT2ANPSR1MAPT
SCHEMBL13784312 0.79 GRM5 (0.42) PARP1MEN1KMT2ANPSR1MAPT
SCHEMBL29541 0.78 PARP1 (0.50) PARP1MEN1KMT2ANPSR1MAPT
SCHEMBL7598089 0.78 PARP1 (0.50) PARP1MEN1KMT2ANPSR1MAPT
SCHEMBL7601076 0.78 PARP1 (0.50) PARP1MEN1KMT2ANPSR1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9711728-B1 Fused thiophene-based conjugated polymers and their use in optoelectronic devices NORTHWESTERN UNIVERSITY (US) 2017-07-18 US disclosed
US-9178160-B1 Fused thiophene-based conjugated polymers and their use in optoelectronic devices NORTHWESTERN UNIVERSITY (US) 2015-11-03 US disclosed