Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 17/20 | 0.69 |
| ▸ | PLK3 | Q9H4B4 | 5/20 | 0.69 |
| ▸ | PLK2 | Q9NYY3 | 5/20 | 0.69 |
| ▸ | REN | P00797 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL464305 | 1.00 | PLK1 (0.69) | PLK1PLK3PLK2REN | |
| SCHEMBL464317 | 1.00 | PLK1 (0.69) | PLK1PLK3PLK2REN | |
| SCHEMBL7855721 | 1.00 | PLK1 (0.69) | PLK1PLK3PLK2REN | |
| SCHEMBL10087709 | 1.00 | PLK1 (0.69) | PLK1PLK3PLK2REN | |
| SCHEMBL464372 | 1.00 | PLK1 (0.69) | PLK1PLK3PLK2REN | |
| SCHEMBL464208 | 1.00 | PLK1 (0.69) | PLK1PLK3PLK2REN | |
| SCHEMBL464083 | 0.99 | PLK1 (0.68) | PLK1PLK3PLK2REN | |
| SCHEMBL464334 | 0.96 | PLK1 (0.63) | PLK1PLK3PLK2REN | |
| SCHEMBL20920259 | 0.93 | PLK1 (0.60) | PLK1PLK3PLK2REN | |
| SCHEMBL20920250 | 0.93 | PLK1 (0.60) | PLK1PLK3PLK2REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9175038-B2 | Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES (US) | 2015-11-03 | — | — | US | disclosed |