Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.62 |
| ▸ | DRD4 | P21917 | 7/20 | 0.53 |
| ▸ | HTR2A | P28223 | 7/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.53 |
| ▸ | HTR2C | P28335 | 5/20 | 0.53 |
| ▸ | HTR1A | P08908 | 5/20 | 0.53 |
| ▸ | DRD2 | P14416 | 4/20 | 0.53 |
| ▸ | HRH2 | P25021 | 3/20 | 0.53 |
| ▸ | HRH1 | P35367 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.53 |
| ▸ | DRD1 | P21728 | 3/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL121054 | 0.90 | HRH4 (0.61) | HRH4DRD4HTR2AADRA2AHTR2C | |
| SCHEMBL122747 | 0.90 | HRH4 (0.61) | HRH4DRD4HTR2AADRA2AHTR2C | |
| SCHEMBL122172 | 0.90 | HRH4 (0.61) | HRH4DRD4HTR2AADRA2AHTR2C | |
| SCHEMBL122693 | 0.90 | HRH4 (0.61) | HRH4DRD4HTR2AADRA2AHTR2C | |
| SCHEMBL122557 | 0.90 | HRH4 (0.61) | HRH4DRD4HTR2AADRA2AHTR2C | |
| SCHEMBL123767 | 0.90 | HRH4 (0.61) | HRH4DRD4HTR2AADRA2AHTR2C | |
| SCHEMBL122746 | 0.90 | HRH4 (0.61) | HRH4DRD4HTR2AADRA2AHTR2C | |
| SCHEMBL122558 | 0.90 | HRH4 (0.61) | HRH4DRD4HTR2AADRA2AHTR2C | |
| SCHEMBL122077 | 0.90 | HRH4 (0.61) | HRH4DRD4HTR2AADRA2AHTR2C | |
| SCHEMBL311420 | 0.90 | HRH4 (0.61) | HRH4DRD4HTR2AADRA2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137180-B1 | DIBENZO [B,F][1,4] OXAZAPINE COMPOUNDS | ARYX THERAPEUTICS INC (US) | 2012-03-07 | — | — | EP | disclosed |