Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 11/20 | 0.40 |
| ▸ | BUB1 | O43683 | 1/20 | 0.37 |
| ▸ | PRKACG | P22612 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | ACSL5 | Q9ULC5 | 1/20 | 0.37 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2396457 | 0.94 | MAPK14 (0.41) | MAPK14CYP2C9MAPK13BUB1PRKACG | |
| SCHEMBL2392468 | 0.88 | MAPK14 (0.40) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL2396282 | 0.87 | MAPK13 (0.40) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL1724436 | 0.86 | MAPK14 (0.35) | MAPK14CYP2C9MAPK13BUB1PRKACG | |
| SCHEMBL2398373 | 0.86 | MAPK14 (0.41) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL2441986 | 0.85 | MAPK13 (0.36) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL1724948 | 0.85 | MAPK14 (0.39) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL2394931 | 0.84 | MAPK14 (0.47) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL1710505 | 0.84 | MAPK14 (0.47) | MAPK14CYP2C9MAPK13MAPK11 | |
| SCHEMBL2394923 | 0.84 | MAPK14 (0.45) | MAPK14CYP2C9MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012980-B2 | Isoquinolinone derivatives | ASTRAZENECA AB (SE) | 2011-09-06 | — | — | US | disclosed |
| EP-2344472-A1 | ISOQUINOLINONE DERIVATIVES | AstraZeneca AB (SE) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010039079-A1 | ISOQUINOLINONE DERIVATIVES | ASTRAZENECA AB (SE) | 2010-04-08 | — | — | WO | disclosed |