Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 16/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6045936 | 0.94 | BDKRB1 (0.88) | BDKRB1CHRM4 | |
| SCHEMBL6046044 | 0.93 | BDKRB1 (0.86) | BDKRB1CHRM4 | |
| SCHEMBL6046018 | 0.92 | BDKRB1 (1.00) | BDKRB1CHRM4 | |
| SCHEMBL6046189 | 0.91 | BDKRB1 (1.00) | BDKRB1 | |
| SCHEMBL6046155 | 0.91 | BDKRB1 (0.82) | BDKRB1CHRM4CHRM2 | |
| SCHEMBL6045867 | 0.91 | BDKRB1 (0.83) | BDKRB1CHRM4CHRM2 | |
| SCHEMBL14085030 | 0.91 | BDKRB1 (0.83) | BDKRB1CHRM4CHRM2 | |
| SCHEMBL6047131 | 0.90 | BDKRB1 (1.00) | BDKRB1CHRM4 | |
| SCHEMBL5820999 | 0.89 | BDKRB1 (0.80) | BDKRB1CHRM4 | |
| SCHEMBL4705088 | 0.88 | BDKRB1 (0.78) | BDKRB1CHRM4CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344176-A1 | USE OF BRADYKININ B1 RECEPTOR ANTAGONISTS IN INTESTINAL FIBROSIS TREATMENT | Jerini AG (DE) | 2011-07-20 | — | — | EP | claimed |
| EP-2344176-A1 | USE OF BRADYKININ B1 RECEPTOR ANTAGONISTS IN INTESTINAL FIBROSIS TREATMENT | Jerini AG (DE) | 2011-07-20 | — | — | EP | disclosed |
| US-7417152-B2 | 4-bromo-5-(2-chloro-benzoylamino)-1H-pyrazole-3-carboxylic acid amide derivatives and related compounds as bradykinin B1 receptor antagonists for the treatment of inflammatory diseases | ELAN PHARMACEUTICALS, INC. (US) | 2008-08-26 | — | — | US | disclosed |
| US-7417152-B2 | 4-bromo-5-(2-chloro-benzoylamino)-1H-pyrazole-3-carboxylic acid amide derivatives and related compounds as bradykinin B1 receptor antagonists for the treatment of inflammatory diseases | ELAN PHARMACEUTICALS, INC. (US) | 2008-08-26 | — | — | US | disclosed |