Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 5/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 9/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14796867 | 0.86 | RET (0.48) | RETCHRM4DGAT1 | |
| SCHEMBL14796986 | 0.84 | PIM1 (0.46) | CHRM4NAMPT | |
| SCHEMBL2405573 | 0.82 | CHRM4 (0.36) | RETCHRM4NAMPT | |
| SCHEMBL1728738 | 0.79 | CHRM4 (0.50) | CHRM4DGAT1CHRM2CHRM1 | |
| SCHEMBL1711018 | 0.79 | CHRM4 (0.57) | CHRM4DGAT1CHRM2CHRM1 | |
| SCHEMBL1728880 | 0.78 | CHRM4 (0.49) | CHRM4CHRM2CHRM1CHRM5CHRM3 | |
| SCHEMBL14796962 | 0.78 | CHRM4 (0.51) | RETCHRM4DGAT1CHRM2CHRM1 | |
| SCHEMBL1728839 | 0.78 | CHRM4 (0.52) | CHRM4CHRM2CHRM1CHRM5CHRM3 | |
| SCHEMBL14796952 | 0.77 | CHRM4 (0.45) | CHRM4DGAT1CHRM2CHRM1CHRM5 | |
| SCHEMBL1711102 | 0.77 | CHRM4 (0.59) | CHRM4DGAT1CHRM2CHRM1CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344486-B1 | ALKYLTHIAZOL CARBAMATE DERIVATIVES, PREPARATION THEREOF AND THEIR USE AS FAAH INHIBITORS | SANOFI SA (FR) | 2013-03-27 | — | — | EP | disclosed |
| EP-2344486-A2 | ALKYLTHIAZOL CARBAMATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010010288-A2 | ALKYLTHIAZOL CARBAMATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-01-28 | — | — | WO | disclosed |