Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 10/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 4/20 | 0.34 |
| ▸ | GSK3B | P49841 | 4/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1725260 | 0.80 | GCK (0.66) | GCK | |
| SCHEMBL1725261 | 0.80 | GCK (0.66) | GCK | |
| SCHEMBL1722766 | 0.76 | GCK (0.41) | GCKIDO1 | |
| SCHEMBL1723258 | 0.73 | GCK (0.40) | GCKSMN1; SMN2KCNH2IDO1NOTUM | |
| SCHEMBL2196405 | 0.72 | GCK (0.62) | GCK | |
| SCHEMBL2196401 | 0.72 | GCK (0.62) | GCK | |
| SCHEMBL26764538 | 0.71 | NOTUM (0.46) | SMN1; SMN2IDO1NOTUM | |
| SCHEMBL2199446 | 0.71 | GCK (0.57) | GCK | |
| SCHEMBL2199454 | 0.71 | GCK (0.57) | GCK | |
| SCHEMBL839388 | 0.70 | NOTUM (0.43) | GCKSMN1; SMN2IDO1NOTUMMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344458-A1 | HETEROARYLS AMIDE DERIVATIVES AND THEIR USE AS GLUCOKINASE ACTIVATORS | Pfizer Inc. (US) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010029461-A1 | HETEROARYLS AMIDE DERIVATIVES AND THEIR USE AS GLUCOKINASE ACTIVATORS | PFIZER INC. (US) | 2010-03-18 | — | — | WO | disclosed |