Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1723265 | 0.84 | CYP1A2 (0.43) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL1711664 | 0.77 | KMT2A (0.44) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL15913994 | 0.72 | DDB1 (0.37) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL15913993 | 0.72 | DDB1 (0.37) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL13833230 | 0.72 | DDB1 (0.37) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL4439245 | 0.69 | MEN1 (0.42) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL13734994 | 0.68 | KMT2A (0.40) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL13458326 | 0.68 | MEN1 (0.40) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL1711337 | 0.68 | KDM4E (0.34) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL1711669 | 0.68 | MEN1 (0.41) | MEN1KMT2AALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344474-A1 | PICOLINAMIDE DERIVATIVES AS KINASE INHIBITORS | Novartis AG (CH) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010026124-A1 | PICOLINAMIDE DERIVATIVES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-03-11 | — | — | WO | disclosed |