Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.71 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.54 |
| ▸ | PDE4A | P27815 | 7/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | MAP3K14 | Q99558 | 4/20 | 0.47 |
| ▸ | PKD1 | P98161 | 2/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17243638 | 0.92 | KCNH2 (0.59) | KCNH2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL17233514 | 0.86 | KCNH2 (0.73) | KCNH2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL17243928 | 0.86 | PDE4B (0.61) | KCNH2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL17233512 | 0.85 | KCNH2 (0.54) | KCNH2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL17233513 | 0.84 | KCNH2 (0.53) | KCNH2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL17243628 | 0.83 | KCNH2 (0.55) | KCNH2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL17243625 | 0.83 | KCNH2 (0.55) | KCNH2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL17243616 | 0.83 | KCNH2 (0.52) | KCNH2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL17243632 | 0.83 | KCNH2 (0.52) | KCNH2PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL717406 | 0.83 | KCNH2 (1.00) | KCNH2PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9181244-B1 | Substituted pyrido[2,3-c]pyridazin-4(1H)-ones as tumor necrosis factor alpha and phosphodiesterase 4 inhibitors | Xuanzhu Pharma Co., Ltd. (CN) | 2015-11-10 | — | — | US | disclosed |
| US-9181244-B1 | Substituted pyrido[2,3-c]pyridazin-4(1H)-ones as tumor necrosis factor alpha and phosphodiesterase 4 inhibitors | Xuanzhu Pharma Co., Ltd. (CN) | 2015-11-10 | — | — | US | disclosed |
| US-9181244-B1 | Substituted pyrido[2,3-c]pyridazin-4(1H)-ones as tumor necrosis factor alpha and phosphodiesterase 4 inhibitors | Xuanzhu Pharma Co., Ltd. (CN) | 2015-11-10 | — | — | US | disclosed |