Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 19/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 6/20 | 0.44 |
| ▸ | DHODH | Q02127 | 4/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17236507 | 0.90 | DHODH (0.43) | CHEK2PARP1DHODH | |
| SCHEMBL17224985 | 0.81 | PARP1 (0.64) | CHEK2PARP1PARP2DHODH | |
| SCHEMBL17224854 | 0.79 | PARP1 (0.49) | PARP1PARP2DHODH | |
| SCHEMBL13778349 | 0.78 | PARP1 (0.52) | CHEK2PARP1PARP2DHODH | |
| SCHEMBL17224941 | 0.75 | PARP1 (0.60) | CHEK2PARP1DHODHHDAC3HDAC4 | |
| SCHEMBL4970975 | 0.74 | PARP1 (0.72) | PARP1PARP2DHODH | |
| SCHEMBL17224889 | 0.71 | DHODH (0.62) | PARP1DHODH | |
| SCHEMBL4975139 | 0.70 | PARP1 (0.75) | PARP1PARP2 | |
| SCHEMBL3150584 | 0.70 | PARP1 (0.71) | CHEK2PARP1PARP2DHODH | |
| SCHEMBL17224960 | 0.69 | DHODH (0.57) | DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015166398-A1 | 3H-IMIDAZO[4,5-B]PYRIDINE DERIVATIVES AS DIHYDROOROTATE DEHYDROGENASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2015-11-05 | — | — | WO | disclosed |