⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11050506 | 0.76 | — | — | |
| SCHEMBL9280706 | 0.74 | — | — | |
| SCHEMBL1767300 | 0.72 | — | — | |
| SCHEMBL1767298 | 0.72 | — | — | |
| SCHEMBL11049831 | 0.69 | — | — | |
| SCHEMBL8191518 | 0.65 | TSHR (0.33) | — | |
| SCHEMBL37331 | 0.65 | — | — | |
| SCHEMBL37332 | 0.65 | — | — | |
| SCHEMBL27320172 | 0.65 | — | — | |
| SCHEMBL4061263 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11123340-B2 | Small-molecule UT-A-selective urea transport inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-09-21 | — | — | US | disclosed |
| US-20200016147-A1 | SMALL-MOLECULE UT-A-SELECTIVE UREA TRANSPORT INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-01-16 | — | — | US | disclosed |
| US-20170239235-A1 | SMALL-MOLECULE UT-A-SELECTIVE UREA TRANSPORT INIHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-08-24 | — | — | US | disclosed |
| WO-2015172065-A1 | SMALL-MOLECULE UT-A-SELECTIVE UREA TRANSPORT INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-11-12 | — | — | WO | disclosed |