Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | PRKACG | P22612 | 1/20 | 0.41 |
| ▸ | PRKACB | P22694 | 1/20 | 0.41 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12991217 | 0.89 | POLB (0.49) | KMT2AMEN1ALDH1A1MAPTHDAC1 | |
| SCHEMBL17241665 | 0.79 | MAPT (0.56) | KMT2AMEN1MAPTHDAC1HDAC8 | |
| SCHEMBL17241980 | 0.77 | MAPT (0.52) | KMT2AMEN1IDO1ALDH1A1MAPT | |
| SCHEMBL17242527 | 0.76 | KMT2A (0.54) | KMT2AMEN1HDAC1HDAC8HDAC6 | |
| SCHEMBL17241832 | 0.75 | PLK1 (0.45) | KMT2AMEN1MAPTHDAC1HDAC8 | |
| SCHEMBL17241739 | 0.75 | MAPT (0.42) | KMT2AMEN1IDO1ALDH1A1MAPT | |
| SCHEMBL17241741 | 0.75 | MAPT (0.42) | KMT2AMEN1IDO1ALDH1A1MAPT | |
| SCHEMBL6510739 | 0.75 | KMT2A (0.72) | KMT2AMEN1ALDH1A1MAPTHDAC1 | |
| SCHEMBL6509732 | 0.70 | MEN1 (0.60) | KMT2AMEN1MAPTHDAC1TP53 | |
| SCHEMBL7708920 | 0.69 | MAPT (0.67) | KMT2AMEN1ALDH1A1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3140301-A1 | PHARMACOLOGICALLY ACTIVE QUINAZOLINEDIONE DERIVATIVES | Orion Corporation (FI) | 2017-03-15 | — | — | EP | claimed |
| WO-2015169999-A1 | PHARMACOLOGICALLY ACTIVE QUINAZOLINEDIONE DERIVATIVES | ORION CORPORATION (FI) | 2015-11-12 | — | — | WO | claimed |