Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.49 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 9/20 | 0.41 |
| ▸ | MTOR | P42345 | 3/20 | 0.41 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL459638 | 0.90 | PIK3CA (0.59) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL457776 | 0.89 | PIK3CD (0.61) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL456997 | 0.81 | PIK3CA (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL10187720 | 0.81 | PIK3CD (0.48) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL463365 | 0.81 | PIK3CD (0.70) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL462573 | 0.80 | PIK3CD (0.66) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL470096 | 0.79 | PIK3CD (0.61) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL463595 | 0.79 | PIK3CD (0.48) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL16667395 | 0.79 | PIK3CD (0.53) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 | |
| SCHEMBL719755 | 0.79 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406255-A1 | 4-OXADIAZOL-2 -YL- INDAZOLES AS INHIBITORS OF P13 KINASES | Glaxo Group Limited (GB) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010102958-A1 | 4-OXADIAZOL-2 -YL- INDAZOLES AS INHIBITORS OF P13 KINASES | GLAXO GROUP LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |