Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 2/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1725218 | 0.91 | MAPK14 (0.47) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL2396466 | 0.88 | MAPK14 (0.47) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL2394531 | 0.87 | MAPK14 (0.48) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL2392911 | 0.81 | MAPK14 (0.44) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL2392345 | 0.81 | MAPK14 (0.44) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL1724625 | 0.81 | GRM2 (0.32) | — | |
| SCHEMBL2394471 | 0.80 | MAPK14 (0.43) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL2394523 | 0.80 | MAPK14 (0.45) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL2393598 | 0.80 | MAPK14 (0.44) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL2417211 | 0.79 | MAPK14 (0.46) | MAPK14CYP2C9MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344472-A1 | ISOQUINOLINONE DERIVATIVES | AstraZeneca AB (SE) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010039079-A1 | ISOQUINOLINONE DERIVATIVES | ASTRAZENECA AB (SE) | 2010-04-08 | — | — | WO | disclosed |