Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.61 |
| ▸ | BTK | Q06187 | 8/20 | 0.61 |
| ▸ | ITK | Q08881 | 7/20 | 0.61 |
| ▸ | JAK2 | O60674 | 1/20 | 0.61 |
| ▸ | LYN | P07948 | 1/20 | 0.61 |
| ▸ | TEC | P42680 | 1/20 | 0.61 |
| ▸ | TXK | P42681 | 1/20 | 0.61 |
| ▸ | BMX | P51813 | 1/20 | 0.61 |
| ▸ | JAK3 | P52333 | 1/20 | 0.61 |
| ▸ | CD69 | Q07108 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17242472 | 0.97 | EGFR (0.59) | EGFRBTKITKJAK2LYN | |
| SCHEMBL17242380 | 0.90 | EGFR (0.50) | EGFRBTKITKJAK2LYN | |
| SCHEMBL17242157 | 0.87 | EGFR (0.57) | EGFRBTKITKJAK2LYN | |
| SCHEMBL17242173 | 0.85 | EGFR (0.49) | EGFRBTKITKJAK2LYN | |
| SCHEMBL19624412 | 0.84 | EGFR (0.63) | EGFRBTKITKJAK2LYN | |
| SCHEMBL17242396 | 0.82 | EGFR (0.46) | EGFRBTKITKJAK2LYN | |
| SCHEMBL17241200 | 0.81 | EGFR (0.77) | EGFRBTKITKJAK2LYN | |
| SCHEMBL17242449 | 0.80 | EGFR (0.43) | EGFRBTKITKJAK2LYN | |
| SCHEMBL19544868 | 0.79 | EGFR (0.66) | EGFRBTKITKJAK2LYN | |
| SCHEMBL17252084 | 0.78 | EGFR (0.72) | EGFRBTKITKJAK2LYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015170266-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AS BTK INHIBITORS | LUPIN LIMITED (IN) | 2015-11-12 | — | — | WO | disclosed |