Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | AKT1 | P31749 | 6/20 | 0.36 |
| ▸ | AKT2 | P31751 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL239482 | 0.82 | AKT1 (0.48) | AKT1AKT2 | |
| SCHEMBL239481 | 0.82 | AKT1 (0.48) | AKT1AKT2 | |
| SCHEMBL235235 | 0.75 | AKT1 (0.48) | NPC1RAB9AMEN1KMT2AAKT1 | |
| SCHEMBL235234 | 0.75 | AKT1 (0.48) | NPC1RAB9AMEN1KMT2AAKT1 | |
| SCHEMBL238558 | 0.75 | AKT1 (0.50) | NPC1RAB9AMEN1KMT2AAKT1 | |
| SCHEMBL238559 | 0.75 | AKT1 (0.50) | NPC1RAB9AMEN1KMT2AAKT1 | |
| SCHEMBL240042 | 0.73 | MAPT (0.55) | MAPTGAANPC1RAB9AMEN1 | |
| SCHEMBL2755184 | 0.73 | MAPT (0.43) | MAPTGAANPC1RAB9AMEN1 | |
| SCHEMBL238464 | 0.72 | GAA (0.42) | MAPTGAANPC1RAB9AMEN1 | |
| SCHEMBL238250 | 0.71 | MAPT (0.55) | MAPTGAANPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406250-A1 | INHIBITORS OF AKT ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2012-01-18 | — | — | EP | claimed |