Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.34 |
| ▸ | SGK1 | O00141 | 1/20 | 0.33 |
| ▸ | BUB1 | O43683 | 1/20 | 0.33 |
| ▸ | PRKACG | P22612 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | ACSL5 | Q9ULC5 | 1/20 | 0.33 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1722189 | 0.91 | MAPK14 (0.48) | MAPK14CYP2C9MAPK13SGK1 | |
| SCHEMBL1710597 | 0.81 | MAPK14 (0.47) | MAPK14CYP2C9MAPK13SGK1 | |
| SCHEMBL2395568 | 0.81 | MAPK14 (0.48) | MAPK14CYP2C9MAPK13SGK1 | |
| SCHEMBL2398076 | 0.81 | MAPK14 (0.47) | MAPK14CYP2C9MAPK13 | |
| SCHEMBL1710598 | 0.79 | MAPK14 (0.46) | MAPK14CYP2C9MAPK13SGK1 | |
| SCHEMBL1726490 | 0.76 | MAPK14 (0.49) | MAPK14CYP2C9MAPK11MAPK13SGK1 | |
| SCHEMBL2394709 | 0.76 | MAPK14 (0.49) | MAPK14CYP2C9MAPK13SGK1 | |
| SCHEMBL2392452 | 0.76 | MAPK14 (0.49) | MAPK14CYP2C9MAPK13SGK1 | |
| SCHEMBL2390226 | 0.76 | MAPK14 (0.55) | MAPK14CYP2C9MAPK11MAPK13SGK1 | |
| SCHEMBL1710670 | 0.75 | MAPK14 (0.48) | MAPK14CYP2C9MAPK13SGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344472-A1 | ISOQUINOLINONE DERIVATIVES | AstraZeneca AB (SE) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010039079-A1 | ISOQUINOLINONE DERIVATIVES | ASTRAZENECA AB (SE) | 2010-04-08 | — | — | WO | disclosed |