Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 18/20 | 0.64 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | PTGES | O14684 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7320347 | 0.79 | PARP1 (1.00) | PARP1PARP2MAP4K4PIM1CLK2 | |
| SCHEMBL12662024 | 0.77 | PARP1 (0.62) | PARP1PARP2SMN1; SMN2PTGES | |
| SCHEMBL12662011 | 0.77 | PARP1 (0.61) | PARP1PARP2SMN1; SMN2PTGES | |
| SCHEMBL12673317 | 0.72 | PARP1 (0.66) | PARP1SMN1; SMN2PTGES | |
| SCHEMBL3150588 | 0.71 | PARP1 (0.61) | PARP1PARP2MAP4K4CSF1RPIM1 | |
| SCHEMBL12662055 | 0.71 | PARP1 (0.51) | PARP1PARP2SMN1; SMN2PTGESMAP4K4 | |
| SCHEMBL12662033 | 0.71 | PARP1 (0.51) | PARP1PARP2SMN1; SMN2PTGESMAP4K4 | |
| SCHEMBL12662054 | 0.71 | PARP1 (0.51) | PARP1PARP2SMN1; SMN2PTGESMAP4K4 | |
| SCHEMBL25217212 | 0.70 | PKN1 (0.66) | PARP1PARP2SMN1; SMN2MAP4K4PIM1 | |
| SCHEMBL30440661 | 0.70 | PKN1 (0.66) | PARP1PARP2SMN1; SMN2MAP4K4PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2746265-B1 | HETEROCYCLIC DERIVATIVE AS MICROSOMAL PROSTAGLANDIN E SYNTHASE (mPGEs) INHIBITOR | NIPPON SHINYAKU CO LTD (JP) | 2015-11-18 | — | — | EP | claimed |