Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | YES1 | P07947 | 1/20 | 0.43 |
| ▸ | FGR | P09769 | 1/20 | 0.43 |
| ▸ | TEC | P42680 | 1/20 | 0.43 |
| ▸ | BMX | P51813 | 1/20 | 0.43 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1726667 | 0.91 | BTK (0.67) | BTKKCNH2 | |
| SCHEMBL3051457 | 0.86 | BTK (0.68) | BTKKCNH2 | |
| SCHEMBL1725882 | 0.79 | BTK (0.65) | BTKKCNH2 | |
| SCHEMBL1727066 | 0.79 | BTK (0.65) | BTKKCNH2 | |
| SCHEMBL13178759 | 0.78 | BTK (0.52) | BTKKCNH2YES1FGRTEC | |
| SCHEMBL18199004 | 0.78 | BTK (0.70) | BTKKCNH2 | |
| SCHEMBL1725805 | 0.75 | BTK (0.55) | BTK | |
| SCHEMBL18198976 | 0.73 | BTK (0.67) | BTKKCNH2 | |
| SCHEMBL3052177 | 0.73 | BTK (0.71) | BTKKCNH2 | |
| SCHEMBL1729634 | 0.72 | BTK (0.72) | BTKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403846-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | F. Hoffmann-La Roche AG (CH) | 2012-01-11 | — | — | EP | disclosed |