Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 11/20 | 0.59 |
| ▸ | KDM6B | O15054 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | KDM4A | O75164 | 1/20 | 0.59 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.59 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL612008 | 0.91 | KDM4C (0.51) | KDM4CKDM6BKDM4EKDM4AKDM4D | |
| SCHEMBL1725204 | 0.84 | MKNK1 (0.49) | KDM4CKDM6BKDM4EMKNK1MKNK2 | |
| SCHEMBL1724418 | 0.81 | KDM4C (0.58) | KDM4CKDM6BKDM4EMKNK1MKNK2 | |
| SCHEMBL1726624 | 0.80 | KDM4C (0.60) | KDM4CKDM6BKDM4EMKNK1MKNK2 | |
| SCHEMBL1724808 | 0.79 | KDM4C (0.53) | KDM4CKDM4EMKNK1MKNK2HPGD | |
| SCHEMBL614610 | 0.76 | MKNK1 (0.49) | KDM4CKDM6BKDM4EMKNK1MKNK2 | |
| SCHEMBL1725706 | 0.74 | IL2 (0.47) | KDM4CKDM6BKDM4EMKNK1MKNK2 | |
| SCHEMBL613989 | 0.72 | KDM6B (0.49) | KDM4CKDM6BKDM4EMKNK1MKNK2 | |
| SCHEMBL2511447 | 0.72 | KDM4C (0.78) | KDM4CKDM6BKDM4EKDM4AKDM4D | |
| SCHEMBL1724770 | 0.72 | MKNK1 (0.56) | KDM4CKDM6BKDM4EKDM4AKDM4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403857-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010101302-A1 | THIENOPYRIMIDINE AS CDC7 KINASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-10 | — | — | WO | disclosed |