Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 19/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1725510 | 0.86 | GCK (0.66) | GCK | |
| SCHEMBL1721931 | 0.83 | GCK (0.53) | GCK | |
| SCHEMBL1726205 | 0.83 | GCK (0.49) | GCK | |
| SCHEMBL1726203 | 0.81 | GCK (0.49) | GCK | |
| SCHEMBL1721828 | 0.80 | GCK (0.59) | GCK | |
| SCHEMBL1723743 | 0.80 | GCK (0.49) | GCK | |
| SCHEMBL1722267 | 0.78 | GCK (0.51) | GCK | |
| SCHEMBL1722190 | 0.77 | GCK (0.81) | GCK | |
| SCHEMBL1724135 | 0.77 | GCK (0.80) | GCK | |
| SCHEMBL1723406 | 0.72 | GCK (0.82) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406230-A1 | SUBSTITUTED INDAZOLE AMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS | Pfizer Inc. (US) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010103438-A1 | SUBSTITUTED INDAZOLE AMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS | PFIZER INC. (US) | 2010-09-16 | — | — | WO | disclosed |