Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18501245 | 0.87 | HRH3 (0.41) | HRH3TSHRPGRKCNH2TP53 | |
| SCHEMBL25461021 | 0.85 | HRH3 (0.33) | HRH3TSHRPGR | |
| SCHEMBL25461022 | 0.85 | HRH3 (0.33) | HRH3TSHRPGR | |
| SCHEMBL12885052 | 0.83 | HRH3 (0.37) | HRH3SLC6A4TSHRPGRKCNH2 | |
| SCHEMBL16997004 | 0.83 | TSHR (0.43) | HRH3TSHRPGRKCNH2TP53 | |
| SCHEMBL25461023 | 0.81 | HRH3 (0.36) | HRH3TSHRPGRKCNH2TP53 | |
| SCHEMBL25461035 | 0.81 | HRH3 (0.36) | HRH3TSHRPGRKCNH2TP53 | |
| SCHEMBL20620368 | 0.80 | SLC6A2 (0.32) | SLC6A4 | |
| SCHEMBL20906895 | 0.79 | HRH3 (0.38) | HRH3PGRKCNH2 | |
| SCHEMBL24854806 | 0.79 | HRH3 (0.38) | HRH3PGRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9187441-B2 | p53-Mdm2 antagonists | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2015-11-17 | — | — | US | disclosed |