Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.45 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1726519 | 1.00 | MTOR (0.54) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL412639 | 0.93 | MTOR (0.61) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL445694 | 0.93 | MTOR (0.61) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL412638 | 0.86 | MTOR (0.65) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL445819 | 0.86 | MTOR (0.65) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL443657 | 0.82 | MTOR (0.64) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL443656 | 0.82 | MTOR (0.64) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL444727 | 0.82 | MTOR (0.68) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL1726518 | 0.80 | MTOR (0.43) | MTORPIK3CACYP3A4 | |
| SCHEMBL413927 | 0.80 | MTOR (0.64) | MTORPIK3CACYP3A4KCNH2RPTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406258-A1 | PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | Cellzome Limited (GB) | 2012-01-18 | — | — | EP | claimed |
| WO-2010103094-A1 | PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | CELLZOME LIMITED (GB) | 2010-09-16 | — | — | WO | claimed |