Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1725713 | 0.87 | BTK (0.75) | BTK | |
| SCHEMBL1726998 | 0.86 | BTK (0.77) | BTK | |
| SCHEMBL1725668 | 0.84 | BTK (0.56) | BTK | |
| SCHEMBL1726804 | 0.81 | BTK (0.58) | BTK | |
| SCHEMBL1725887 | 0.81 | BTK (0.77) | BTK | |
| SCHEMBL1727065 | 0.80 | BTK (0.55) | BTK | |
| SCHEMBL1725880 | 0.80 | BTK (0.54) | BTK | |
| SCHEMBL1725063 | 0.79 | BTK (0.56) | BTK | |
| SCHEMBL1725805 | 0.78 | BTK (0.55) | BTK | |
| SCHEMBL13178761 | 0.77 | BTK (0.60) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403846-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | F. Hoffmann-La Roche AG (CH) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010100070-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2010-09-10 | — | — | WO | disclosed |