Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.77 |
| ▸ | RAF1 | P04049 | 12/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1012417 | 0.92 | BRAF (0.78) | BRAFRAF1 | |
| Hydrochloric Acid SCHEMBL1012478 | 0.92 | BRAF (0.78) | BRAFRAF1 | |
| SCHEMBL1781226 | 0.87 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL1013405 | 0.87 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL1013403 | 0.87 | BRAF (1.00) | BRAFRAF1 | |
| Hydrochloric Acid SCHEMBL1067145 | 0.86 | BRAF (0.99) | BRAFRAF1 | |
| Hydrochloric Acid SCHEMBL1013092 | 0.86 | BRAF (0.99) | BRAFRAF1 | |
| Hydrochloric Acid SCHEMBL1014960 | 0.86 | BRAF (0.99) | BRAFRAF1 | |
| Hydrochloric Acid SCHEMBL1014959 | 0.86 | BRAF (0.99) | BRAFRAF1 | |
| Hydrochloric Acid SCHEMBL1013090 | 0.86 | BRAF (0.99) | BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3147281-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2017-03-29 | — | — | EP | disclosed |
| EP-2947072-A1 | 1-(3-(6,7-DIMETHOXYQUINAZOLIN-4-YLOXY)PHENYL)-3-(5-(1,1,1-TRIFLUORO-2-METHYLPROPAN-2-YL)ISOXAZOL-3-YL)UREA AS RAF KINASE MODULATOR IN THE TREATMENT OF CANCER DISEASES | Ambit Biosciences Corporation (US) | 2015-11-25 | — | — | EP | disclosed |