Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 17/20 | 0.55 |
| ▸ | KLK1 | P06870 | 5/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17268030 | 1.00 | KLKB1 (0.55) | KLKB1KLK1PSMB5 | |
| SCHEMBL14485575 | 0.89 | KLKB1 (0.56) | KLKB1KLK1PSMB5 | |
| SCHEMBL15901579 | 0.89 | KLKB1 (0.56) | KLKB1KLK1PSMB5 | |
| SCHEMBL14485384 | 0.85 | KLKB1 (0.74) | KLKB1KLK1 | |
| SCHEMBL14485377 | 0.85 | KLKB1 (0.74) | KLKB1KLK1 | |
| SCHEMBL15901128 | 0.81 | KLKB1 (0.69) | KLKB1KLK1 | |
| SCHEMBL14485573 | 0.81 | KLKB1 (0.58) | KLKB1KLK1 | |
| SCHEMBL15901058 | 0.81 | KLKB1 (0.58) | KLKB1KLK1 | |
| SCHEMBL15901801 | 0.77 | KLKB1 (0.77) | KLKB1KLK1 | |
| SCHEMBL15901410 | 0.76 | KLKB1 (0.87) | KLKB1KLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2729443-B3 | BENZYLAMINE DERIVATIVES AS INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LTD (GB) | 2020-02-12 | — | — | EP | disclosed |
| EP-2729443-B1 | BENZYLAMINE DERIVATIVES AS INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LTD (GB) | 2015-11-25 | — | — | EP | disclosed |