Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 5/20 | 0.56 |
| ▸ | MAP4K1 | Q92918 | 7/20 | 0.49 |
| ▸ | IL2 | P60568 | 4/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.39 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL15557566 | 0.99 | ALK (0.55) | ALKMAP4K1IL2BRD4BCL2A1 | |
| SCHEMBL15599345 | 0.92 | ALK (0.55) | ALKMAP4K1IL2BRD4CCNT1 | |
| SCHEMBL17273490 | 0.91 | ALK (0.57) | ALKMAP4K1IL2BCL2A1MAPK1 | |
| SCHEMBL17273500 | 0.91 | ALK (0.57) | ALKMAP4K1IL2BCL2A1ACVR1 | |
| Hydrochloric Acid SCHEMBL15557537 | 0.91 | ALK (0.56) | ALKMAP4K1IL2BCL2A1ACVR1 | |
| Hydrochloric Acid SCHEMBL17273444 | 0.91 | ALK (0.56) | ALKMAP4K1IL2BCL2A1MAPK1 | |
| SCHEMBL17273492 | 0.89 | ALK (0.70) | ALKMAP4K1IL2BCL2A1MAPK1 | |
| Hydrochloric Acid SCHEMBL17273481 | 0.88 | ALK (0.69) | ALKMAP4K1IL2BCL2A1MAPK1 | |
| SCHEMBL17273457 | 0.88 | ALK (0.60) | ALKMAP4K1IL2MAPK1MAP3K11 | |
| SCHEMBL17273378 | 0.87 | ALK (0.51) | ALKMAP4K1IL2BRD4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9353107-B2 | 3-(pyrazolyl)-1H-pyrrolo[2,3-b]pyridine derivatives as kinase inhibitors | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2016-05-31 | — | — | US | claimed |
| US-20150336949-A1 | 3-(Pyrazolyl)-1H-Pyrrolo[2,3-b]Pyridine Derivatives as Kinase Inhibitors | Um Pharmauji Sdn. Bhd. (MY) | 2015-11-26 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150336949-A1 | 3-(Pyrazolyl)-1H-Pyrrolo[2,3-b]Pyridine Derivatives as Kinase Inhibitors | MAP3K3, MAP3K1, MAP3K6 | ALK 408/4885MAP4K1 27/4885IL2 3532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.