Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 4/20 | 0.34 |
| ▸ | IKBKB | O14920 | 2/20 | 0.34 |
| ▸ | F7 | P08709 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 4/20 | 0.33 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.33 |
| ▸ | F3 | P13726 | 2/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14565 | 0.95 | CHEK2 (0.39) | CHEK2CHUKIKBKBF7ALDH1A1 | |
| SCHEMBL14357 | 0.91 | KIT (0.35) | CHUKIKBKBF7KITSUCNR1 | |
| SCHEMBL14216 | 0.85 | CHEK2 (0.39) | CHEK2CHUKF7F3CYP3A4 | |
| SCHEMBL12062173 | 0.82 | KCNA5 (0.35) | CHEK2CHUKKITINSRMAPK8 | |
| SCHEMBL17277137 | 0.82 | TLR7 (0.36) | KDM4EABL1EGFRSRCABL2 | |
| SCHEMBL14300 | 0.82 | EGFR (0.34) | KITKDM4EABL1EGFRSRC | |
| SCHEMBL12062128 | 0.82 | SRC (0.38) | CHUKKITINSRMAPK8CAMKK2 | |
| SCHEMBL14477 | 0.81 | SRC (0.35) | ALDH1A1KITKDM4EABL1EGFR | |
| SCHEMBL13966 | 0.81 | SRC (0.38) | CHUKKITINSRMAPK8CAMKK2 | |
| SCHEMBL20082539 | 0.80 | SRC (0.34) | KITKDM4EABL1EGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9193731-B2 | Antimicrobial compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2015-11-24 | — | — | US | disclosed |