Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 7/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.43 |
| ▸ | PRKCA | P17252 | 5/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 9/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9882073 | 0.91 | PRKCQ (0.48) | PRKCQPRKCDPRKCAFLT3GSK3B | |
| SCHEMBL9882262 | 0.89 | PARP1 (0.42) | PRKCQPRKCDPRKCAFLT3GSK3B | |
| SCHEMBL9882072 | 0.89 | PRKCQ (0.47) | PRKCQPRKCDPRKCAFLT3GSK3B | |
| SCHEMBL9882081 | 0.89 | PRKCQ (0.45) | PRKCQPRKCDPRKCAFLT3GSK3B | |
| SCHEMBL9882069 | 0.85 | PIM1 (0.51) | PRKCQPRKCDPRKCAFLT3GSK3B | |
| SCHEMBL9882074 | 0.84 | MAPT (0.49) | PRKCQPRKCDPRKCAFLT3GSK3B | |
| SCHEMBL9882298 | 0.83 | PRKCQ (0.43) | PRKCQPRKCDPRKCAFLT3GSK3B | |
| SCHEMBL9883356 | 0.83 | PRKCQ (0.42) | PRKCQPRKCDPRKCAFLT3GSK3B | |
| SCHEMBL9882292 | 0.83 | PIM1 (0.47) | PRKCQPRKCDPRKCAFLT3GSK3B | |
| SCHEMBL9882297 | 0.83 | PIM1 (0.47) | PRKCQPRKCDPRKCAFLT3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9193722-B2 | Tri-cyclic pyrazolopyridine kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-11-24 | — | — | US | disclosed |
| US-9193722-B2 | Tri-cyclic pyrazolopyridine kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-11-24 | — | — | US | disclosed |