Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 17/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 12/20 | 0.44 |
| ▸ | PRKCA | P17252 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | PKLR | P30613 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17277172 | 1.00 | PRKCQ (0.44) | PRKCQPRKCDPRKCAMAPTTLR9 | |
| SCHEMBL9882314 | 0.91 | PRKCQ (0.44) | PRKCQPRKCDPRKCAMAPTTLR9 | |
| SCHEMBL15273721 | 0.91 | PRKCQ (0.44) | PRKCQPRKCDPRKCAMAPT | |
| SCHEMBL15273738 | 0.91 | PRKCQ (0.44) | PRKCQPRKCDPRKCAMAPT | |
| SCHEMBL9882145 | 0.90 | PRKCQ (0.43) | PRKCQPRKCDPRKCAMAPTTLR9 | |
| SCHEMBL9882144 | 0.90 | PRKCQ (0.43) | PRKCQPRKCDPRKCAMAPTTLR9 | |
| SCHEMBL17277171 | 0.90 | PRKCQ (0.43) | PRKCQPRKCDPRKCAMAPTTLR9 | |
| SCHEMBL9882239 | 0.89 | PRKCQ (0.43) | PRKCQPRKCDPRKCAMAPT | |
| SCHEMBL9882326 | 0.88 | PRKCQ (0.42) | PRKCQPRKCDPRKCAMAPTTLR9 | |
| SCHEMBL9882151 | 0.84 | PRKCQ (0.44) | PRKCQPRKCDPRKCAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9193722-B2 | Tri-cyclic pyrazolopyridine kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-11-24 | — | — | US | disclosed |
| US-9193722-B2 | Tri-cyclic pyrazolopyridine kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-11-24 | — | — | US | disclosed |