Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 17/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 12/20 | 0.47 |
| ▸ | PRKCA | P17252 | 5/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | PRKCB | P05771 | 1/20 | 0.42 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9882036 | 1.00 | PRKCQ (0.47) | PRKCQPRKCDPRKCAFLT3PRKCB | |
| SCHEMBL9882037 | 1.00 | PRKCQ (0.47) | PRKCQPRKCDPRKCAFLT3PRKCB | |
| SCHEMBL9882268 | 0.91 | PRKCQ (0.46) | PRKCQPRKCDPRKCAFLT3PRKCB | |
| SCHEMBL15273585 | 0.90 | PRKCQ (0.47) | PRKCQPRKCDPRKCAFLT3PRKCB | |
| SCHEMBL9882083 | 0.90 | PRKCQ (0.47) | PRKCQPRKCDPRKCAFLT3PRKCB | |
| SCHEMBL9882029 | 0.90 | PRKCQ (0.47) | PRKCQPRKCDPRKCAFLT3PRKCB | |
| SCHEMBL15273584 | 0.90 | PRKCQ (0.47) | PRKCQPRKCDPRKCAFLT3PRKCB | |
| SCHEMBL9882031 | 0.90 | PRKCQ (0.47) | PRKCQPRKCDPRKCAFLT3PRKCB | |
| SCHEMBL9882089 | 0.90 | PRKCQ (0.47) | PRKCQPRKCDPRKCAFLT3PRKCB | |
| SCHEMBL15273789 | 0.90 | PRKCQ (0.53) | PRKCQPRKCDPRKCAFLT3PRKCB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9193722-B2 | Tri-cyclic pyrazolopyridine kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-11-24 | — | — | US | disclosed |
| US-9193722-B2 | Tri-cyclic pyrazolopyridine kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-11-24 | — | — | US | disclosed |