Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 5/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CCR5 | P51681 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | UBE2M | P61081 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12075657 | 0.94 | SLC6A2 (0.48) | SLC6A2SLC6A4KCNH2SLC6A3DRD2 | |
| SCHEMBL17277595 | 0.93 | SLC6A2 (0.49) | SLC6A2SLC6A4KCNH2SLC6A3DRD2 | |
| SCHEMBL17277564 | 0.88 | SLC6A2 (0.51) | SLC6A2SLC6A4KCNH2SLC6A3DRD2 | |
| SCHEMBL12075428 | 0.88 | SLC6A2 (0.50) | SLC6A2SLC6A4KCNH2SLC6A3DRD2 | |
| SCHEMBL12062015 | 0.85 | SLC6A2 (0.48) | SLC6A2SLC6A4KCNH2SLC6A3DRD2 | |
| SCHEMBL17277279 | 0.83 | SLC6A2 (0.49) | SLC6A2SLC6A4KCNH2SLC6A3ALDH1A1 | |
| SCHEMBL17277491 | 0.83 | SLC6A2 (0.54) | SLC6A2SLC6A4KCNH2SLC6A3CACNA1B | |
| SCHEMBL17277400 | 0.82 | HTR2A (0.48) | SLC6A2SLC6A4KCNH2SLC6A3DRD2 | |
| SCHEMBL17277488 | 0.81 | HTR2A (0.49) | SLC6A2SLC6A4KCNH2SLC6A3DRD2 | |
| SCHEMBL12062064 | 0.79 | PSEN1 (0.47) | SLC6A2SLC6A4KCNH2SLC6A3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9193731-B2 | Antimicrobial compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2015-11-24 | — | — | US | disclosed |