Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 19/20 | 0.55 |
| ▸ | HCRTR2 | O43614 | 19/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12327656 | 1.00 | HCRTR1 (0.55) | HCRTR1HCRTR2CHEK2 | |
| SCHEMBL16215441 | 1.00 | HCRTR1 (0.55) | HCRTR1HCRTR2CHEK2 | |
| SCHEMBL1293520 | 0.97 | HCRTR1 (0.58) | HCRTR1HCRTR2 | |
| SCHEMBL38658108 | 0.97 | HCRTR1 (0.58) | HCRTR1HCRTR2 | |
| SCHEMBL204028 | 0.97 | HCRTR1 (0.58) | HCRTR1HCRTR2 | |
| SCHEMBL2706134 | 0.97 | HCRTR1 (0.58) | HCRTR1HCRTR2 | |
| SCHEMBL12567373 | 0.92 | HCRTR1 (0.47) | HCRTR1HCRTR2CHEK2 | |
| SCHEMBL1357197 | 0.89 | HCRTR1 (0.56) | HCRTR1HCRTR2CHEK2 | |
| SCHEMBL1357196 | 0.89 | HCRTR1 (0.56) | HCRTR1HCRTR2CHEK2 | |
| SCHEMBL1982286 | 0.89 | HCRTR1 (0.49) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2545060-B1 | FUSED TRICYCLIC SILYL COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME (US) | 2015-11-25 | — | — | EP | disclosed |