Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 9/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | STK16 | O75716 | 1/20 | 0.55 |
| ▸ | LATS1 | O95835 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.55 |
| ▸ | MST1R | Q04912 | 1/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.55 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.55 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.55 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.55 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.55 |
| ▸ | ADCK1 | Q86TW2 | 1/20 | 0.55 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.55 |
| ▸ | NEK9 | Q8TD19 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.55 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12235929 | 0.88 | SYK (0.58) | SYKPLK4AURKASTK16LATS1 | |
| SCHEMBL12212791 | 0.87 | SYK (0.59) | SYKPLK4AURKASTK16LATS1 | |
| SCHEMBL22618969 | 0.84 | SYK (0.78) | SYKPLK4AURKASTK16LATS1 | |
| SCHEMBL12212800 | 0.77 | SYK (0.49) | SYKPLK4AURKASTK16LATS1 | |
| SCHEMBL12237030 | 0.76 | SYK (0.46) | SYKPLK4AURKASTK16LATS1 | |
| SCHEMBL17277982 | 0.73 | SYK (0.70) | SYKPLK4AURKASTK16LATS1 | |
| SCHEMBL12237027 | 0.72 | SYK (0.74) | SYKPLK4AURKASTK16LATS1 | |
| SCHEMBL12212783 | 0.72 | SYK (0.74) | SYKPLK4AURKASTK16LATS1 | |
| SCHEMBL12212808 | 0.72 | SYK (0.47) | SYKPLK4AURKASTK16LATS1 | |
| SCHEMBL2536722 | 0.72 | SYK (0.69) | SYKPLK4AURKASTK16LATS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558474-B1 | 2, 4-PYRIMIDINEDIAMINE COMPOUNDS AND PRODRUGS THEREOF AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2015-11-25 | — | — | EP | disclosed |