Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 14/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2103803 | 0.94 | SYK (0.55) | MAOBADORA2ASYKEGFRJAK2 | |
| SCHEMBL12212798 | 0.89 | SYK (0.49) | MAOBADORA2ASYKEGFRJAK2 | |
| SCHEMBL2101323 | 0.87 | MAOB (0.51) | MAOBADORA2ASYKEGFRJAK2 | |
| SCHEMBL2103481 | 0.87 | MAOB (0.51) | MAOBADORA2ASYKEGFRJAK2 | |
| SCHEMBL3951884 | 0.87 | MAOB (0.51) | MAOBADORA2ASYKEGFRJAK2 | |
| SCHEMBL2101544 | 0.86 | SYK (0.61) | MAOBADORA2ASYKEGFRJAK2 | |
| SCHEMBL2102368 | 0.86 | SYK (0.61) | MAOBADORA2ASYKEGFRJAK2 | |
| SCHEMBL2100628 | 0.85 | AURKA (0.57) | MAOBADORA2ASYKEGFRJAK2 | |
| SCHEMBL2100735 | 0.84 | BCL6 (0.56) | SYKEGFR | |
| SCHEMBL2745277 | 0.84 | SYK (0.47) | MAOBADORA2ASYKEGFRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558474-B1 | 2, 4-PYRIMIDINEDIAMINE COMPOUNDS AND PRODRUGS THEREOF AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2015-11-25 | — | — | EP | disclosed |