Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 17/20 | 0.48 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | TOP2A | P11388 | 2/20 | 0.31 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1727910 | 1.00 | GSK3B (0.48) | GSK3BTNKSTOP2ATOP2B | |
| SCHEMBL1720692 | 0.89 | GSK3B (0.59) | GSK3B | |
| SCHEMBL1724593 | 0.89 | GSK3B (0.59) | GSK3B | |
| SCHEMBL3076770 | 0.89 | GSK3B (0.59) | GSK3B | |
| SCHEMBL13153667 | 0.84 | GSK3B (0.58) | GSK3B | |
| SCHEMBL1724888 | 0.84 | GSK3B (0.58) | GSK3B | |
| SCHEMBL1723979 | 0.81 | GSK3B (0.56) | GSK3B | |
| SCHEMBL1720882 | 0.81 | GSK3B (0.56) | GSK3B | |
| SCHEMBL3091328 | 0.81 | GSK3B (0.56) | GSK3B | |
| SCHEMBL3091339 | 0.81 | GSK3B (0.56) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2406266-A1 | 7-CYCLOALKYLAMINOQUINOLONES AS GSK-3 INHIBITORS | Kyorin Pharmaceutical Co., Ltd. (JP) | 2012-01-18 | — | — | EP | disclosed |
| WO-2010104205-A1 | 7-CYCLOALKYLAMINOQUINOLONES AS GSK-3 INHIBITORS | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2010-09-16 | — | — | WO | disclosed |