⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2405901 | 0.80 | — | — | |
| SCHEMBL6076999 | 0.78 | — | — | |
| SCHEMBL10819086 | 0.77 | TSHR (0.31) | — | |
| SCHEMBL14721206 | 0.74 | — | — | |
| SCHEMBL3692679 | 0.73 | — | — | |
| SCHEMBL25056795 | 0.72 | TP53 (0.35) | — | |
| SCHEMBL609519 | 0.71 | TSHR (0.38) | — | |
| SCHEMBL1126983 | 0.71 | TSHR (0.38) | — | |
| SCHEMBL20017949 | 0.69 | — | — | |
| SCHEMBL5933249 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4227293-A2 | CRYSTALLINE FORMS OF 1-(ACYLOXY)-ALKYL CARBAMATE DRUG CONJUGATES OF NAPROXEN AND PREGABALIN | Xgene Pharmaceutical Inc (KY) | 2023-08-16 | — | — | EP | disclosed |
| EP-4227293-A2 | CRYSTALLINE FORMS OF 1-(ACYLOXY)-ALKYL CARBAMATE DRUG CONJUGATES OF NAPROXEN AND PREGABALIN | Xgene Pharmaceutical Inc (KY) | 2023-08-16 | — | — | EP | disclosed |
| US-20210238136-A1 | AZETIDINE DERIVATIVE, AND PRODRUG THEREOF | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2021-08-05 | — | — | US | disclosed |
| US-20210221768-A1 | CRYSTALLINE FORMS OF 1-(ACYLOXY)-ALKYL CARBAMATE DRUG CONJUGATES OF NAPROXEN AND PREGABALIN | XGENE PHARMACEUTICAL INC. (KY) | 2021-07-22 | — | — | US | disclosed |
| US-11053249-B2 | Proteasome inhibiting β-lactam prodrugs useful for the treatment of cancer and neurodegenerative disorders | PHILIPPE YVES-REMY SIMON (FR) | 2021-07-06 | — | — | US | disclosed |
| US-11053249-B2 | Proteasome inhibiting β-lactam prodrugs useful for the treatment of cancer and neurodegenerative disorders | PHILIPPE YVES-REMY SIMON (FR) | 2021-07-06 | — | — | US | disclosed |
| EP-3805203-A1 | AZETIDINE DERIVATIVE, AND PRODRUG THEREOF | Daiichi Sankyo Company, Limited (JP) | 2021-04-14 | — | — | EP | disclosed |
| EP-3793974-A1 | CRYSTALLINE FORMS OF 1-(ACYLOXY)-ALKYL CARBAMATE DRUG CONJUGATES OF NAPROXEN AND PREGABALIN | Xgene Pharmaceutical Inc (KY) | 2021-03-24 | — | — | EP | disclosed |
| US-20200216455-A1 | Proteasome Inhibiting Beta-Lactam Produrgs Useful for the Treatment of Cancer and Nurodegenerative Disorders | VITA API (FR) | 2020-07-09 | — | — | US | disclosed |
| US-20200216455-A1 | Proteasome Inhibiting Beta-Lactam Produrgs Useful for the Treatment of Cancer and Nurodegenerative Disorders | VITA API (FR) | 2020-07-09 | — | — | US | disclosed |
| US-8268887-B2 | Drug conjugates and methods of use thereof | KYPHIA PHARMACEUTICALS, INC. (KY) | 2012-09-18 | — | — | US | disclosed |
| EP-2403481-A1 | ORAL DOSAGE FORMS HAVING A HIGH LOADING OF A GABAPENTIN PRODRUG | XenoPort, Inc. (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2010102252-A1 | ORAL DOSAGE FORMS HAVING A HIGH LOADING OF A GABAPENTIN PRODRUG | XENOPORT, INC. (US) | 2010-09-10 | — | — | WO | disclosed |
| US-20100226981-A1 | ORAL DOSAGE FORMS HAVING A HIGH LOADING OF A GABAPENTIN PRODRUG | XENOPORT, INC. (US) | 2010-09-09 | — | — | US | disclosed |
| US-7749985-B2 | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use | XENOPORT, INC. (US) | 2010-07-06 | — | — | US | disclosed |
| US-20100113497-A1 | GABA CONJUGATES AND METHODS OF USE THEREOF | KYPHIA PHARMACEUTICALS, INC. (US) | 2010-05-06 | — | — | US | disclosed |
| US-20090286759-A1 | ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE | XENOPORT, INC. (US) | 2009-11-19 | — | — | US | disclosed |
| US-7585996-B2 | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use | XENOPORT, INC. (US) | 2009-09-08 | — | — | US | disclosed |
| US-20080146526-A1 | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use | XENOPORT, INC. | 2008-06-19 | — | — | US | disclosed |
| WO-2008033572-A1 | ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE | XENOPORT, INC. (US) | 2008-03-20 | — | — | WO | disclosed |