⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4957834 | 0.72 | — | — | |
| SCHEMBL668 | 0.72 | — | — | |
| SCHEMBL5248398 | 0.67 | — | — | |
| SCHEMBL1394407 | 0.67 | — | — | |
| Ethylene Glycol SCHEMBL2307225 | 0.67 | — | — | |
| SCHEMBL25420124 | 0.67 | — | — | |
| SCHEMBL25388502 | 0.67 | — | — | |
| SCHEMBL6603911 | 0.67 | — | — | |
| Water SCHEMBL21050625 | 0.67 | — | — | |
| SCHEMBL9642247 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148995-B1 | 6-SUBSTITUTED-3H-1,3-BENZOTHIAZOL-2-ONE COMPOUNDS AS TARP-GAMMA 8 DEPENDENT AMPA RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2020-09-23 | — | — | EP | claimed |
| EP-3148995-A1 | 6-SUBSTITUTED-3H-1,3-BENZOTHIAZOL-2-ONE COMPOUNDS AS TARP-GAMMA 8 DEPENDENT AMPA RECEPTOR ANTAGONISTS | Eli Lilly and Company (US) | 2017-04-05 | — | — | EP | claimed |
| US-9469632-B2 | 6-substituted-3H-1,3-benzothiazol-2-one compounds as TARP-gamma 8 dependent AMPA receptor antagonists | ELI LILLY AND COMPANY (US) | 2016-10-18 | — | — | US | claimed |
| WO-2015183673-A1 | 6-SUBSTITUTED-3H-1,3-BENZOTHIAZOL-2-ONE COMPOUNDS AS TARP-GAMMA 8 DEPENDENT AMPA RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2015-12-03 | — | — | WO | claimed |
| US-20150344468-A1 | 6-SUBSTITUTED-3H-1,3-BENZOTHIAZOL-2-ONE COMPOUNDS AS TARP-GAMMA 8 DEPENDENT AMPA RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY | 2015-12-03 | — | — | US | claimed |
| CN-116143804-B | Tetracyclic quinolone compound, pharmaceutically acceptable salt and application thereof | 核新生物医药(长春)有限公司 | 2024-03-29 | — | — | CN | disclosed |
| CN-116143804-A | Tetracyclic quinolone compound, pharmaceutically acceptable salt and application thereof | 核新生物医药(长春)有限公司 | 2023-05-23 | — | — | CN | disclosed |
| EP-3148995-B1 | 6-SUBSTITUTED-3H-1,3-BENZOTHIAZOL-2-ONE COMPOUNDS AS TARP-GAMMA 8 DEPENDENT AMPA RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2020-09-23 | — | — | EP | disclosed |
| EP-3148995-A1 | 6-SUBSTITUTED-3H-1,3-BENZOTHIAZOL-2-ONE COMPOUNDS AS TARP-GAMMA 8 DEPENDENT AMPA RECEPTOR ANTAGONISTS | Eli Lilly and Company (US) | 2017-04-05 | — | — | EP | disclosed |
| US-9469632-B2 | 6-substituted-3H-1,3-benzothiazol-2-one compounds as TARP-gamma 8 dependent AMPA receptor antagonists | ELI LILLY AND COMPANY (US) | 2016-10-18 | — | — | US | disclosed |
| WO-2015183673-A1 | 6-SUBSTITUTED-3H-1,3-BENZOTHIAZOL-2-ONE COMPOUNDS AS TARP-GAMMA 8 DEPENDENT AMPA RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2015-12-03 | — | — | WO | disclosed |
| US-20150344468-A1 | 6-SUBSTITUTED-3H-1,3-BENZOTHIAZOL-2-ONE COMPOUNDS AS TARP-GAMMA 8 DEPENDENT AMPA RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY | 2015-12-03 | — | — | US | disclosed |