Phlorizin

Phlorizin

SCHEMBL17290

O=C(CCc1ccc(O)cc1)c1c(O)cc(O)cc1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SLC5A1 P13866 14/20 1.00
SLC5A2 P31639 5/20 1.00
SLC28A3 Q9HAS3 3/20 1.00
HPGD P15428 2/20 1.00
HSD17B10 Q99714 2/20 1.00
KDM4E B2RXH2 1/20 1.00
CYP3A4 P08684 1/20 1.00
MAPT P10636 1/20 1.00
THRB P10828 1/20 1.00
CYP2C9 P11712 1/20 1.00
CYP2C19 P33261 1/20 1.00
SLC28A2 O43868 1/20 1.00
EPHX2 P34913 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phlorizin SCHEMBL18058585 1.00 SLC5A1 (1.00) SLC5A1SLC5A2SLC28A3HPGDHSD17B10
Phlorizin SCHEMBL16421567 1.00 SLC5A1 (1.00) SLC5A1SLC5A2SLC28A3HPGDHSD17B10
Phlorizin SCHEMBL113699 1.00 SLC5A1 (1.00) SLC5A1SLC5A2SLC28A3HPGDHSD17B10
Phlorizin SCHEMBL2826870 1.00 SLC5A1 (1.00) SLC5A1SLC5A2SLC28A3HPGDHSD17B10
Phlorizin SCHEMBL22022720 1.00 SLC5A1 (1.00) SLC5A1SLC5A2SLC28A3HPGDHSD17B10
Phlorizin SCHEMBL23802544 1.00 SLC5A1 (1.00) SLC5A1SLC5A2SLC28A3HPGDHSD17B10
Phlorizin SCHEMBL7647026 0.99 SLC5A1 (0.98) SLC5A1SLC5A2SLC28A3HPGDHSD17B10
Phlorizin SCHEMBL28823647 0.99 SLC5A1 (0.98) SLC5A1SLC5A2SLC28A3HPGDHSD17B10
Phlorizin SCHEMBL18523288 0.99 SLC5A1 (0.98) SLC5A1SLC5A2SLC28A3HPGDHSD17B10
Phlorizin SCHEMBL8861774 0.99 SLC5A1 (0.98) SLC5A1SLC5A2SLC28A3HPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 10007 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122080093-A Compounds effective in treating liver toxicity and fatty liver disease and uses thereof 2026-05-26 CN claimed
CN-117903218-B New orange peel Process for preparing glycoside GUILIN LAYN NATURAL INGREDIENTS CORP. (CN) 2026-05-26 CN claimed
CN-117903219-B Preparation method of phlorizin-4' -beta-neohesperidin GUILIN LAYN NATURAL INGREDIENTS CORP. (CN) 2026-05-26 CN claimed
CN-122038177-A Bacillus synthetic flora, composite microbial inoculant and application thereof 山东农业大学 2026-05-15 CN claimed
CN-122031436-A Application of phloretin in preparation of medicament for improving muscular atrophy 南京大学 2026-05-15 CN claimed
EP-4739449-A1 METHOD FOR MANUFACTURING AN UPSET-FORGED PART AND ASSEMBLY FOR IMPLEMENTING THE METHOD SAFRAN AIRCRAFT ENGINES (FR) 2026-05-13 EP claimed
CN-122012432-A Phloretin enzyme activity related protein, and coding gene and application thereof 中国中医科学院中药研究所 2026-05-12 CN claimed
CN-122004374-A Preparation method of apple juice, apple juice and beverage 内蒙古伊利实业集团股份有限公司 2026-05-12 CN claimed
EP-4493800-B1 DOUBLE ACTING MULTI-TEMPERATURE PISTON RABHI VIANNEY (FR) 2026-04-22 EP claimed
CN-121575079-A SGLT1/2 double-target inhibitor, screening method and application thereof, and diabetes treatment drug 广东药科大学 2026-02-27 CN claimed
US-5036861-A Method and apparatus for non-invasively monitoring plasma glucose levels SEMBROWICH WALTER L (US) 1991-08-06 US claimed
CN-1051503-A Disease and treatment of diseases NORPHARMCO INC (CA) 1991-05-22 CN claimed
WO-1991004058-A2 TREATMENT OF CONDITIONS AND DISEASE NORPHARMCO INC. (CA) 1991-04-04 WO claimed
US-4959355-A GLUCOSE TRANSPORT BLOCKER THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 1990-09-25 US claimed
US-4840939-A Treatment of cancer with phlorizin and its derivatives LEVEEN HARRY H (US) 1989-06-20 US claimed
EP-0291151-A1 Compositions comprising phlorizin derivatives for treatment of cancer Leveen, Harry H. (US) 1988-11-17 EP claimed
US-4684627-A Treatment of cancer with phlorizin and its derivatives MEDICINAL DEVELOPMENTS,INC. 1987-08-04 US claimed
EP-0172721-A2 Use of phlorizin or its derivatives in combination with a chemotherapeutic agent for the treatment of cancer Leveen, Harry H. (US) 1986-02-26 EP claimed
US-4565806-A Composition and method for rational treatment of cancer SETAELAE KAI M E 1986-01-21 US claimed
US-4152869-A Propagating woody plant material NATIONAL SEED DEVELOPMENT ORGANISATION LIMITED (GB) 1979-05-08 US claimed