Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.34 |
| ▸ | F2R | P25116 | 13/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1730671 | 0.86 | KDM4E (0.45) | F2RKDM4EMAPTRAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5488069 | 0.84 | KDM4E (0.47) | F2RKDM4EMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL1731025 | 0.83 | KDM4E (0.44) | F2RKDM4EMAPTRAB9ASMN1; SMN2 | |
| Bromide SCHEMBL1729353 | 0.82 | KDM4E (0.46) | F2RKDM4EMAPTRAB9ASMN1; SMN2 | |
| Bromide SCHEMBL1730470 | 0.82 | KDM4E (0.44) | F2RKDM4EMAPTRAB9ASMN1; SMN2 | |
| Bromide SCHEMBL1729263 | 0.82 | KDM4E (0.41) | F2RKDM4EMAPTRAB9ASMN1; SMN2 | |
| Bromide SCHEMBL5494451 | 0.82 | F2R (0.41) | F2RKDM4EMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL5490666 | 0.81 | KDM4E (0.48) | F2RKDM4EMAPTRAB9ASMN1; SMN2 | |
| Bromide SCHEMBL1730702 | 0.81 | F2R (0.48) | F2RKDM4EMAPTRAB9ASMN1; SMN2 | |
| Bromide SCHEMBL1729410 | 0.81 | F2R (0.43) | F2RKDM4EMAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391451-B1 | 2-IMINOPYRROLIDINE DERIVATES | EISAI R&D MAN CO LTD (JP) | 2011-11-23 | — | — | EP | disclosed |