Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.64 |
| ▸ | FLT1 | P17948 | 1/20 | 0.64 |
| ▸ | KDR | P35968 | 1/20 | 0.64 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.64 |
| ▸ | CDK8 | P49336 | 1/20 | 0.64 |
| ▸ | GSK3A | P49840 | 1/20 | 0.64 |
| ▸ | GSK3B | P49841 | 1/20 | 0.64 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.64 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.64 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.64 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17290901 | 1.00 | CSF1R (0.64) | CSF1RFGFR1FLT1KDRCSNK1A1 | |
| SCHEMBL8888266 | 0.85 | CSF1R (0.66) | CSF1RFGFR1FLT1KDRCSNK1A1 | |
| SCHEMBL1574797 | 0.82 | CYP1A2 (0.63) | CSF1RFGFR1FLT1KDRCSNK1A1 | |
| SCHEMBL15656069 | 0.82 | KDR (0.71) | CSF1RFGFR1FLT1KDRCSNK1A1 | |
| SCHEMBL17290973 | 0.81 | POLB (0.46) | CSF1RFGFR1FLT1KDRCSNK1A1 | |
| SCHEMBL17295125 | 0.80 | SCN9A (0.44) | CSF1RFGFR1FLT1KDRCSNK1A1 | |
| SCHEMBL17290240 | 0.80 | SCN9A (0.44) | CSF1RFGFR1FLT1KDRCSNK1A1 | |
| SCHEMBL4707932 | 0.78 | CDK8 (1.00) | CSF1RFGFR1FLT1KDRCSNK1A1 | |
| SCHEMBL17290254 | 0.77 | CSF1R (0.44) | CSF1RFGFR1FLT1KDRCSNK1A1 | |
| SCHEMBL17290253 | 0.77 | CSF1R (0.44) | CSF1RFGFR1FLT1KDRCSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148972-A1 | PYRAZOLONE DERIVATIVES AS NITROXYL DONORS | Cardioxyl Pharmaceuticals Inc. (US) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015183839-A1 | PYRAZOLONE DERIVATIVES AS NITROXYL DONORS | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2015-12-03 | — | — | WO | disclosed |