Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.70 |
| ▸ | CA2 | P00918 | 4/20 | 0.70 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17296508 | 0.89 | HSP90AA1 (0.60) | CA1CA2HSP90AA1RAB9AKMT2A | |
| SCHEMBL16585699 | 0.88 | CA1 (0.72) | CA1CA2HSP90AA1RAB9AKMT2A | |
| SCHEMBL17296522 | 0.88 | CA1 (0.58) | CA1CA2HSP90AA1RAB9AKMT2A | |
| SCHEMBL18320469 | 0.87 | KMT2A (0.69) | RAB9AKMT2AGAALMNASLC6A2 | |
| SCHEMBL17296505 | 0.86 | CA1 (0.66) | CA1CA2HSP90AA1RAB9AKMT2A | |
| SCHEMBL31715823 | 0.84 | TDP1 (0.69) | RAB9AKMT2AGAALMNASLC6A2 | |
| SCHEMBL20401143 | 0.84 | MAPT (0.62) | CA1CA2HSP90AA1RAB9AKMT2A | |
| SCHEMBL2643145 | 0.83 | CA1 (1.00) | CA1CA2RAB9AKMT2ALMNA | |
| SCHEMBL17296524 | 0.83 | CA1 (0.61) | CA1CA2HSP90AA1RAB9AKMT2A | |
| SCHEMBL10392942 | 0.83 | KMT2A (0.65) | CA1CA2RAB9AKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112979510-A | Sulfonamide compounds and their use as STAT5 inhibitors | 多伦多大学管理委员会 | 2021-06-18 | — | — | CN | disclosed |
| EP-3148967-B1 | SULFONAMIDE COMPOUNDS AND THEIR USE AS STAT5 INHIBITORS | GOVERNING COUNCIL UNIV TORONTO (CA) | 2019-10-02 | — | — | EP | disclosed |
| EP-3148967-B1 | SULFONAMIDE COMPOUNDS AND THEIR USE AS STAT5 INHIBITORS | GOVERNING COUNCIL UNIV TORONTO (CA) | 2019-10-02 | — | — | EP | disclosed |
| US-20170101369-A1 | SULFONAMIDE COMPOUNDS AND THEIR USE AS STAT5 INHIBITORS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2017-04-13 | — | — | US | disclosed |
| US-20170101369-A1 | SULFONAMIDE COMPOUNDS AND THEIR USE AS STAT5 INHIBITORS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2017-04-13 | — | — | US | disclosed |
| US-20170101369-A1 | SULFONAMIDE COMPOUNDS AND THEIR USE AS STAT5 INHIBITORS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2017-04-13 | — | — | US | disclosed |
| EP-3148967-A1 | SULFONAMIDE COMPOUNDS AND THEIR USE AS STAT5 INHIBITORS | The Governing Council of the University of Toronto (CA) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015179956-A1 | SULFONAMIDE COMPOUNDS AND THEIR USE AS STAT5 INHIBITORS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2015-12-03 | — | — | WO | disclosed |
| WO-2015179956-A1 | SULFONAMIDE COMPOUNDS AND THEIR USE AS STAT5 INHIBITORS | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2015-12-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170101369-A1 | SULFONAMIDE COMPOUNDS AND THEIR USE AS STAT5 INHIBITORS | STAT5A, STAT5B, JAK2 | CA1 3070/4885CA2 2340/4885HSP90AA1 1757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.