Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.65 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15783588 | 1.00 | BACE1 (0.65) | BACE1BACE2KCNH2 | |
| SCHEMBL15769615 | 0.92 | BACE1 (0.65) | BACE1BACE2KCNH2 | |
| SCHEMBL15783587 | 0.92 | BACE1 (0.64) | BACE1BACE2KCNH2 | |
| SCHEMBL17296549 | 0.92 | BACE1 (0.64) | BACE1BACE2KCNH2 | |
| SCHEMBL15783583 | 0.92 | BACE1 (0.65) | BACE1BACE2KCNH2 | |
| SCHEMBL17296550 | 0.92 | BACE1 (0.65) | BACE1BACE2KCNH2 | |
| SCHEMBL15783578 | 0.90 | BACE1 (0.72) | BACE1BACE2KCNH2 | |
| SCHEMBL15986242 | 0.90 | BACE1 (0.72) | BACE1BACE2KCNH2 | |
| SCHEMBL17296544 | 0.90 | BACE1 (0.72) | BACE1BACE2KCNH2 | |
| SCHEMBL17296552 | 0.89 | BACE1 (0.53) | BACE1BACE2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9198917-B2 | Hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds | PFIZER INC. (US) | 2015-12-01 | — | — | US | disclosed |
| US-9198917-B2 | Hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds | PFIZER INC. (US) | 2015-12-01 | — | — | US | disclosed |