Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.50 |
| ▸ | PIK3C3 | Q8NEB9 | 13/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | ULK1 | O75385 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | KRAS | P01116 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | YES1 | P07947 | 1/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17296640 | 0.87 | BRAF (0.43) | BRAFNR1I2MAPK14PLK4EPHB6 | |
| SCHEMBL17296644 | 0.86 | BRAF (0.60) | BRAFPIK3C3NR1I2MAPK14RAF1 | |
| SCHEMBL17685154 | 0.86 | BRAF (0.60) | BRAFPIK3C3NR1I2MAPK14 | |
| SCHEMBL17296645 | 0.85 | BRAF (0.72) | BRAFPIK3C3NR1I2MAPK14RAF1 | |
| SCHEMBL17296647 | 0.82 | BRAF (0.57) | BRAFPIK3C3NR1I2MAPK14RAF1 | |
| SCHEMBL17297141 | 0.82 | BRAF (0.71) | BRAFPIK3C3NR1I2PLK4EPHB6 | |
| SCHEMBL17296643 | 0.80 | BRAF (0.51) | BRAFPIK3C3NR1I2MAPK14RAF1 | |
| SCHEMBL17297171 | 0.79 | BRAF (0.51) | BRAFNR1I2RAF1 | |
| SCHEMBL17296632 | 0.78 | BRAF (0.35) | BRAFNR1I2MAPK14 | |
| SCHEMBL17296630 | 0.77 | BRAF (0.37) | BRAFNR1I2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2678336-B1 | THIAZOLYLPHENYL-BENZENESULFONAMIDO DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2016-04-20 | — | — | EP | disclosed |
| US-9199979-B2 | Thiazolylphenyl-benzenesulfonamido derivatives as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-12-01 | — | — | US | disclosed |
| US-9199979-B2 | Thiazolylphenyl-benzenesulfonamido derivatives as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-12-01 | — | — | US | disclosed |