Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1729694 | 0.83 | KDM4E (0.32) | KDM4EMAPTRAB9ANPC1SMN1; SMN2 | |
| Bromide SCHEMBL1731156 | 0.81 | KDM4E (0.33) | KDM4EMAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL28740933 | 0.79 | KDM4E (0.32) | KDM4EMAPTRAB9ANPC1SMN1; SMN2 | |
| Bromide SCHEMBL5494446 | 0.78 | F2R (0.38) | KDM4EMAPTRAB9ANPC1SMN1; SMN2 | |
| Bromide SCHEMBL1732098 | 0.77 | KDM4E (0.34) | KDM4EMAPTRAB9ANPC1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5486707 | 0.77 | F2R (0.37) | KDM4EMAPTRAB9ASMN1; SMN2 | |
| Bromide SCHEMBL1731357 | 0.76 | KDM4E (0.33) | KDM4EMAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL14449067 | 0.75 | F2R (0.45) | KDM4EMAPTRAB9ANPC1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1729247 | 0.74 | F2R (0.44) | KDM4EMAPTRAB9ASMN1; SMN2 | |
| Bromide SCHEMBL1730666 | 0.73 | F2R (0.35) | KDM4EMAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391451-B1 | 2-IMINOPYRROLIDINE DERIVATES | EISAI R&D MAN CO LTD (JP) | 2011-11-23 | — | — | EP | disclosed |