Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.83 |
| ▸ | NR1I2 | O75469 | 6/20 | 0.66 |
| ▸ | PIK3C3 | Q8NEB9 | 8/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17297146 | 0.93 | BRAF (0.89) | BRAFNR1I2PIK3C3 | |
| SCHEMBL17297142 | 0.92 | BRAF (0.83) | BRAFNR1I2PIK3C3 | |
| SCHEMBL17297167 | 0.92 | BRAF (0.70) | BRAFNR1I2PIK3C3 | |
| SCHEMBL17297154 | 0.91 | BRAF (0.70) | BRAFNR1I2PIK3C3 | |
| SCHEMBL17685150 | 0.91 | BRAF (0.85) | BRAFNR1I2PIK3C3 | |
| SCHEMBL17297148 | 0.91 | BRAF (1.00) | BRAFNR1I2PIK3C3 | |
| SCHEMBL17297200 | 0.89 | BRAF (0.66) | BRAFNR1I2 | |
| SCHEMBL17297202 | 0.89 | BRAF (0.65) | BRAFNR1I2 | |
| SCHEMBL17297184 | 0.87 | BRAF (0.64) | BRAFNR1I2 | |
| SCHEMBL17297189 | 0.87 | BRAF (0.64) | BRAFNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2678336-B1 | THIAZOLYLPHENYL-BENZENESULFONAMIDO DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2016-04-20 | — | — | EP | claimed |
| EP-2678336-B1 | THIAZOLYLPHENYL-BENZENESULFONAMIDO DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2016-04-20 | — | — | EP | disclosed |
| US-9199979-B2 | Thiazolylphenyl-benzenesulfonamido derivatives as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-12-01 | — | — | US | disclosed |